Group I— untreated

Group II— ERB treated

Group III— healthy

Group IV— sham-op

Group V— ARB treated

Group VI— water-therapy

Group VII— ERB + ARB

Body weight (g)

466.0 ± 6.7

540.0 ± 8.8^*

576.8 ± 20.8^*

585.8 ± 6.8^*

540.5 ± 19.6^*

569.8 ± 10.1^*

540.5 ± 19.6^*

SBP (mmHg)

177.7 ± 4.9

132.2 ± 5.2

100.8 ± 8.2^*

104.8 ± 8.4^*

102.3 ± 13.1^*

125.2 ± 15.4^*

101.8 ± 3.4^*

Crea (micromol/l)

99.4 ± 28.9

57.3 ± 3.0^*

31.4 ± 7.2^*

43.2 ± 7.9^*

57.4 ± 5.7^*

58.1 ± 0.91^*

57.4 ± 5.7^*

UProt (g/24h)

7.6 ± 4.2

4.9 ± 1.4

0.3 ± 0.5^*

0.8 ± 0.5^*

2.1 ± 1.0^*

2.0 ± 1.2^*

1.8 ± 0.8^*

Interstitial fibrosis

1.8 ± 0.5

1.2 ± 0.5

0.0 ± 0.0^*

0.0 ± 0.0^*

0.5 ± 0.7^*

0.6 ± 0.4^*

0.5 ± 0.3^*